The main symptoms and signs of the disease have edema, jaundice, anemia and hepatosplenomegaly. The severity of the symptoms depends on the number of antibodies, the maturity of the newborn and the compensatory hematopoiesis.
1. Jaundice is the main symptom of ABO hemolytic disease, and most of them appear on the 2~3 day after birth. In the first days after birth, jaundice accounted for about 1/4. Similarly, severe jaundice was also around 1/4. In the 4-5 day, jaundice reached its peak, mainly with moderate degree, and a few was severe. Jaundice can have serious antifeedant and poor response, screaming, jiaogongfanzhang, convulsions and other nuclear jaundice.
2, anemia ABO hemolytic disease patients have different degrees of anemia, but the general degree is lighter, severe anemia (the hemoglobin below 100g/L) only accounts for about 5%.
Some cases of ABO hemolytic disease, early symptoms is not heavy, but after 2 ~ 6 weeks after birth or late anemia, 8 ~ 12 weeks of physiological anemia anemia "period was particularly serious, this is because the blood type antibody persists, causes red blood cells to shorten the life span of occurrence caused by slow hemolysis. It is reported that the life span of these children's red blood cells is only about 35 days, and the daily hemoglobin decrease is about 4 times higher than that of the normal children. The destruction of red blood cells increases. When the hematopoietic function of bone marrow is low, it can't compensate effectively, and eventually lead to late anemia.
3, the breathing is rapid, the heart rate is quicker.
4, hepatosplenomegaly and bone marrow hematopoietic tissue showed compensatory hyperplasia, therefore cause varying degrees of hepatosplenomegaly, microscopic examination of liver and spleen, lung, pancreas, kidney and other tissue found in extramedullary hematopoietic foci.