Why does it lead to thrombocytopenia?

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asked in Others by thrombocytopenia

3 Answers

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answered by DIANNA
Premature destruction of platelets or excessive consumption of platelets leads to thrombocytopenia in the surrounding blood. Platelet life is shortened, and the number of megakaryocytes in bone marrow is normal or compensatory hyperplasia. Because of the complex symptoms of thrombocytopenia, the etiology of thrombocytopenia is also very complicated. What are the causes of thrombocytopenia?
Immunodestruction: a drug related antibody that produces a corresponding antibody. Immune thrombocytopenia can be caused by some abnormal immune response diseases. Infection associated thrombocytopenia is common in virus and bacterial infections. Immunological thrombocytopenia, after transfusion of purpura and neonate purpura, is the cause of thrombocytopenia.
Non immune destruction: the vascular intima is rough, and the intravascular foreign bodies cause mechanical destruction of the platelets. The causes of thrombocytopenia include vasculitis, artificial heart valves, arterial cannulation, cardiopulmonary bypass, hemodialysis, etc. Disseminated intravascular coagulation, thrombotic thrombocytopenic purpura and hemolytic uremic syndrome are all associated with thrombocytopenia, which is associated with excessive platelet consumption.
Causes of thrombocytopenia in vivo platelet production, such as bone marrow problems, patients suffering from aplastic anemia, Yao lead to bone marrow damage, cancer (leukemia) or other cancers. Thrombocytopenia is the cause of thrombocytopenia, such as immune thrombocytopenia, which is generally the most common thrombocytopenic purpura.
The platelet content of normal people is 150x109 per liter of blood. If it falls to 50x10 (9 power), the body will suffer from some collisions and it will easily become black. If it falls to 10x109, it will easily bleed, and the situation is very serious. The common symptoms of low platelet are subcutaneous and mucosal parts, such as nasal and oral teeth, which are easy to bleed, while intra articular bleeding can lead to joint swelling and thrombocytopenia.
Acute type ITP occurs mostly in the recovery period of virus infection or upper respiratory tract infection, such as rash, measles, chickenpox, parotid cancer and so on. Patients had higher antiviral antibodies in the serum. Thrombocytopenia, including increased platelet surface associated antibodies, was thought to be caused by viral antigens. The pathogenesis may be antigen antibody complexes including viral antigens, which react with platelet Fc receptors or autoantibodies produced by virus antigens, react with platelet membrane, damage platelets and be cleared away by phagocytes.
There is no history of prodrome infection before the onset of chronic ITP, which is caused by autoantibodies caused by changes in platelet structural antigen. The 80% to 90% medical records had platelet surface related antibodies, of which 95% were PalgG, 2/3 was PalgG and PalgM, and a few were PalgA and PAC. The antibody acts directly on the glycoprotein of platelet membrane. A small number of interactions with Gbib complex make platelet life shortened and function change are the causes of thrombocytopenia.
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answered by DESIREE
Thrombocytopenia is found in a variety of blood diseases, rheumatoid immune diseases, radiotherapy and chemotherapy injury, and drug related thrombocytopenia. They can show internal bleeding, such as hematemesis, melena, hematuria and cerebral hemorrhage, severe life-threatening health! There must be a cause, and what is the cause of that platelet reduction? Please see the exclusive analysis of Li Wenyu, a specialist in the Ji'nan blood disease hospital.
Three major causes of thrombocytopenia
Reason 1, thrombocytopenia decrease or invalid death: including two kinds of hereditary and acquired. The decrease of acquired thrombocytopenia is due to some factors, such as drugs, malignant tumor, infection and ionizing radiation, which damage hematopoietic stem cells or influence their proliferation in bone marrow. These factors can affect multiple hematopoietic cell systems, often accompanied by different levels of anemia, leukocyte reduction, and bone marrow megakaryocyte significantly reduced.
Cause 2, excessive platelet destruction, including two species of congenital and acquired. The overabundance of acquired thrombocytopenia includes immune and non immune. Excessive thrombocytopenia and thrombocytopenia are common in immune thrombocytopenia. The excessive destruction of non immune thrombocytopenia includes infection, diffuse intravascular coagulation, thrombotic thrombocytopenic purpura, and so on.
Cause 3, platelets remain in the spleen too much: the most common in the hypersplenism.
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answered by MONA
Thrombocytopenia may be due to three reasons: platelet production deficiency, spleen on platelet retention, and increased platelet destruction or using diluted. Common drugs cause drug-induced bone marrow regeneration: low or low barriers with pancytopenia. Chemicals and drugs again low bone marrow, easy to cause in a certain dose such as benzene, xylene and other drugs. Can cause aplastic bone marrow or low: such as chloramphenicol, sulfonamides and penicillin.
The treatment of thrombocytopenia with etiology and severity and changeable, the need to quickly identify the etiology, if possible, should be corrected. Adults usually start treatment of oral corticosteroids (such as prednisone daily 1mg/kg). Such as, the platelet count will return to normal in 2~6 weeks, and then gradually decline. But the effect of corticosteroids in most patients is not enough satisfied, or reduce the dose of adrenal steroid after recurrence.
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