What are neutrophils, low neutrophil in our life situation see, the low neutrophil is aware of it, the reason for low neutrophil to understand how much, let us try to understand the neutrophils.
In our usual life, physical examination in the hospital, our blood, the blood routine examination data, doctors can more accurately help us determine the physical problem, which is the percentage of neutrophils in our daily life frequently encountered symptoms, generally by a cold virus is likely to cause such symptoms.
What is the low percentage of neutrophils
Neutrophils originate in bone marrow hematopoietic stem cells
Neutrophils originate in the bone marrow hematopoietic stem cells and enter the blood or tissue after the differentiation and development of the bone marrow. The number of distribution in the bone marrow, blood and connective tissue ratio is 28:1:25, the total number of Yuezhanbai neutrophils in the blood of 55% adults 70%.
Neutrophils are one of the polymorphonuclear leukocytes, with the largest number in the granulocytes, so some people refer to polymorphonuclear leukocytes to neutrophils. The cells contain many unique particles dispersed small pink or light purple, particles containing myeloperoxidase, acid phosphatase, lysozyme and phagocytin etc..
Myeloperoxidase specific neutrophils, even in macrophages that are strong in few or without this enzyme, are phagocytic. Cytochemistry, which is usually marked by the myeloperoxidase in neutrophils. Neutrophils have strong chemotaxis.
The so-called chemotaxis is the movement of a cell in the direction of a chemical substance. Substances that play a chemotaxis to neutrophils are called neutrophil chemokines. There is a chemokine receptor on the neutral cell membrane, which binds with chemokines, activates the calcium pump on the cell membrane, and extends the cells to the front foot to make the cells move towards the location of chemokine.
After contacting with the foreign bodies that produce chemokines, the cytoplasm of the neutrophilic cells form a protrusions around the contact points, namely, the pseudo fovea, the cell membrane underlying the contact part, and the foreign bodies surrounded, forming the phagocytic bodies or phagocytic vesicles containing foreign bodies. The membrane of neutrophils has IgGFc receptor and complement C3 receptor on the surface of neutrophil, which can accelerate phagocytosis.
When the phagocytic foreign body is wrapped with antibodies and complement, it binds with the corresponding receptors on the neutrophil membrane, and strengthens the phagocytosis of cells, which is called conditioning.
The respiratory burst caused by the disorder of the cell membrane as the cell phagocytosis begins.
With the initiation of cell phagocytosis, the respiratory burst caused by the disorder of cell membrane and the increase of oxygen consumption of cells lead to a large number of peroxide and superoxide and other cytotoxic effector molecules, which have cytotoxic activity to parasites. Stimulated by interferon - gamma and tumor necrosis factor, it can produce more anions of oxygen metabolism and kill extracellular parasites.
Neutrophils also die after killing foreign bodies such as phagocytic bacteria, and the dead neutrophils are called purulent cells.
When neutrophils are affected by bacterial products and antigen antibody complexes, the granular content of the cells is released to the cells. The release of acidic protease and neutral protease can decompose the vascular basement membrane, glomerular basement membrane, collagen and elastin in connective tissue, complement C5, C15 and kinin in plasma.
Some of the decomposition products are neutrophil chemokines, which can attract more neutrophils. Among the substances released from neutrophils, there are eosinophil chemokines, neutrophil immobility factor (NIF), kininogen, plasminogen, coagulation factor and leukotriene.