Not every infected person will have a complete four stage performance, but each stage of the disease can be seen in the clinic. The different clinical manifestations of the four periods are a progressive and coherent course of development.
1. stage of acute infection
The window period is also at this time. The response of HIV to the body's stimulation after the invasion of the human body. Patients with fever, rash, lymph node enlargement, fatigue, sweating, nausea, vomiting, diarrhea, pharyngitis and so on. Some also appear acute aseptic meningitis, which is characterized by headache, neurogenic symptoms and meningeal irritation. At the end of the blood test, the total number of leukocytes was normal, or the lymphocyte decreased, and the mononuclear cells increased. At the time of acute infection, the symptoms are often mild and easy to be ignored. After infected 2--6 weeks, the serum HIV antibody showed positive reaction. Since then, there is a relatively healthy, asymptomatic incubation period.
(1) skin damage in the period of acute infection of AIDS
The mucous membrane of the skin is one of the main parts of the invasion of AIDS. Skin damage is mainly characterized by rash, mostly itchy red erythematous papules, and occasionally diffuse urticaria or water herpes. Skin lesions occur mostly in the face, trunk and heavy body. Many AIDS patients are the first symptom of skin damage.
(2) systemic symptoms in the period of AIDS acute infection
Systemic symptoms include: sore throat, fever, night sweats, joint pain, lymphadenopathy and hepatosplenomegaly. Chronic diarrhea is also a very obvious early clinical manifestation of some AIDS patients. The most common clinical symptoms of AIDS patients are recurrent low fever, chills, emaciation, fatigue, weight loss (5~22 kg), lethargy, weakness, inability to support normal physical activity, and no fever, diarrhea and weight loss.
(3) central nervous system symptoms during acute infection
About 9% of patients with nervous system injury may have acute HIV meningitis. The clinical manifestations are fever, headache, vomiting and meningeal irritation. Cerebrospinal fluid examination shows increased mononuclear cells and increased protein content. The above symptoms can be recovered by themselves after 2~3 weeks. The clinical manifestations of 20% to 40% of AIDS patients have neurologic diseases. The disorder of the nerve has been recognized as a common cause of disease and death in AIDS patients. The symptoms of the central nervous system coexist with the symptoms of various opportunistic infections, and are more common with subacute encephalitis.
(4) lymph node enlargement in acute infection period
The incidence of generalized lymphadenopathy, which is not explained by other reasons, is likely to be associated with HIV infection, with a incidence of 55% to 100%. The degree of lymph node enlargement is associated with the level of HIV antibody titer in the serum, often in the posterior cervical, submaxillary or subaxillary lymph nodes. The swollen lymph nodes are not fused, hard, even tenderness, and the surface of the skin is not changed.
2. incubation period
Latent period is also known as asymptomatic infection period. The infected person can not have any clinical symptoms, but the incubation period is not static, nor is it safe. The virus has a strong destructive effect in continuous reproduction. The incubation period refers to the time from infected HIV to the onset of clinical symptoms and signs of AIDS. The average incubation period of AIDS is now considered to be 2--10. This is very difficult for the early detection of patients and prevention. After the incubation period, 50% of the people will develop into AIDS within 8 years. It has been reported that from 1 to 7 years, the rate of infection from infection to disease is 1.5%, 5%, 10%, 15%, 25%, 30% and 40%. The incubation period of AIDS in children is short, with an average of 12 months. At this time, a very sensitive method was used to detect the number of virus nuclear wakes in the plasma of HIV infected people, and it could predict the incidence of the disease within 5 years.
3. prophase of AIDS
After the incubation period, signs and symptoms associated with AIDS, obviously, it was known as the AIDS related syndrome, also known as persistent generalized lymphadenopathy. The main manifestations are: persistent lymphatic enlargement, starting in the neck, and next to axillary and inguinal lymph nodes. In general, there are less than two cases of lymph node enlargement. The weight loss was over 10%. Periodic fever (about 38 degrees centigrade), often lasts for several months. Night sweats. There are various infections such as herpes simplex virus, Candida albicans (fungi) and so on.
4. typical AIDS period
As the immune system is seriously damaged, all kinds of fatal opportunistic infections, tumors and so on are very easy to occur. The lesions can be seen on the lungs, the mouth, the digestive system, the nervous system, the endocrine system, the heart, the kidneys, the eyes, the joints, the skin and so on. The average survival period was 9 months in the patients with opportunistic infection.
AIDS is not invincible, as long as the timely discovery of the early symptoms of AIDS, and establish the correct faith, some AIDS can be treated well, provided of course that we pay more attention to AIDS, grasp the early symptoms of AIDS, and apply to practice.
AIDS symptoms are not a problem, only by testing to determine whether you are infected. After the clinical statistics, many HIV infected people have no symptoms of AIDS awareness in the incubation period, but there are also some people early in the infection may have early symptoms of AIDS have a fever, sore throat, dizziness, weakness, joint pain, rash, superficial lymph nodes and other similar "cold", some people can the occurrence of diarrhea. The symptoms of AIDS usually disappear after 1-2 weeks, and then the patients turn to the latent period of no AIDS symptoms.
The common symptoms of aids include the following aspects: